The short answer: published human research on oxygenated water is limited, and the results are mixed. Most controlled studies have not found a consistent improvement in exercise performance or broad health outcomes. A few studies have reported narrower signals—such as faster post-exercise lactate clearance or a smaller drop in blood oxygen saturation under simulated low-oxygen conditions—but those findings are not the same as proving better hydration, greater endurance, or a general health benefit.
The most important point: none of the studies summarized below tested Nano Fit Water or Nano Fit’s specific combination of dissolved oxygen and oxygen nanobubbles.
First, “oxygenated water” is not one standardized product
In research, the term oxygenated water can refer to products made by different processes, containing very different oxygen concentrations, and consumed in different amounts. Some studies used bottled water with elevated dissolved oxygen. Others used a small-volume oxygen supplement. Study participants ranged from recreational exercisers to trained runners, and the testing conditions ranged from sea-level exercise to simulated altitude.
Because the formulations and protocols are not interchangeable, a result from one study cannot automatically be applied to every oxygenated-water product.
What controlled studies found about exercise performance
Most trials did not show a meaningful performance improvement
A 2021 randomized, double-blind crossover study tested two waters containing approximately 110 mg of oxygen per liter against a control water containing about 10 mg/L. Twenty men drank the assigned water before performing high-intensity exercise to exhaustion. The researchers found no significant difference in time to exhaustion, cardiopulmonary response, arterial lactate, blood gases, or pH. They also found no evidence of increased oxidative damage at rest. Read the study.
An earlier study involving nine recreational male cyclists tested oxygenated water during exercise under hypoxic, or reduced-oxygen, conditions. Performance, hydration measures, and blood oxygenation were not improved. Read the study.
Other small controlled trials reached similar conclusions. A 2006 laboratory study found no enhancement of aerobic performance or lactate kinetics, and a 2007 study of 11 active men found no improvement in submaximal or maximal cycling performance. Read the 2006 study and the 2007 study.
What this means: current evidence does not support claiming that oxygenated water reliably makes healthy people faster, stronger, or able to exercise longer.
A narrower recovery signal: lactate clearance
A 2017 randomized, double-blind crossover study followed 25 trained male runners during a 5,000-meter treadmill time trial. Participants consumed either an oxygen supplement solution or a taste-matched placebo before, during, and after the trial.
The supplement did not improve running time or muscle oxygen saturation. However, blood lactate cleared more quickly during the 30-minute recovery period. The effect sizes were small, and the study did not test whether the faster clearance improved performance in a later workout. The study was sponsored by the beverage company that supplied the supplement. Read the full open-access study.
This is an interesting finding, but it needs independent replication using clearly characterized products and a study design that measures whether the laboratory change produces a meaningful recovery or performance benefit.
Blood oxygen under simulated low-oxygen conditions
A 2022 randomized, placebo-controlled, single-blind trial studied 22 healthy adults walking under normobaric hypoxic conditions—an indoor simulation of reduced oxygen availability. The group drinking oxygenated mineral water experienced a smaller decrease in pulse-oximeter oxygen saturation than the control group. There was no significant difference in walking distance, and pulse rate increased more in the oxygenated-water group.
The study was funded by an oxygenated-water company, although the authors reported that they were not company employees and received no honoraria. Read the full study.
What it does not prove: this small trial does not establish a benefit during ordinary daily activity at sea level, and it does not show that oxygenated water improves athletic performance.
What research says about general health and safety
A 2005 randomized, double-blind study followed 24 adults who drank either oxygenated water or normal mineral water for 28 days. Researchers found no apparent harmful effect on liver enzymes, blood counts, or the immune system. Some immune markers differed between groups, but the sample was small and the results are not enough to establish a clinical health benefit. Read the study.
A systematic review covering research available through July 2022 identified only four eligible oxygenated-water studies among healthy populations. Its overall conclusion was that the available evidence did not establish additional health effects compared with mineral water. Read the systematic review.
The limited number of qualifying studies matters. “No established benefit” does not mean every possible effect has been disproved. It means the evidence is not yet strong or consistent enough to support broad claims.
Where oxygen nanobubbles fit—and where they do not
Most human studies on oxygenated water have focused on dissolved oxygen. Nano Fit uses a dual-oxygen approach: dissolved oxygen plus oxygen nanobubbles. Those are different physical forms of oxygen in water, but that distinction cannot be used as a shortcut to claim a human benefit.
Published physical-science research confirms that oxygen nanobubbles can exist in water and that their stability depends on factors such as mineral hardness, pH, temperature, dissolved substances, and storage conditions. For example, a 2021 Water Research study tracked oxygen nanobubble concentration and size under different freshwater conditions and found that water chemistry materially affected stability. Read the nanobubble stability study.
That research helps explain nanobubble behavior in water. It does not prove that drinking oxygen nanobubbles improves hydration, oxygen delivery, exercise performance, recovery, or any medical outcome. Those questions require human studies using the actual finished product.
What would stronger evidence look like?
A useful product-specific study would need to report:
- The exact dissolved-oxygen concentration at the time of consumption.
- Independent verification of nanobubble size, concentration, and stability.
- A randomized, blinded, placebo-controlled design.
- A sample size large enough to detect a meaningful effect.
- Clearly defined outcomes, not a large list of exploratory measurements.
- Independent replication and transparent disclosure of funding.
The finished Nano Fit product would need to be tested directly before results could reasonably be presented as evidence about Nano Fit.
The bottom line
The published evidence does not support sweeping claims that oxygenated water broadly improves health or exercise performance. It does contain a few limited findings worth studying further, particularly around lactate clearance and blood oxygen saturation under simulated hypoxia. The evidence base is still small, formulations vary widely, and the findings have not established Nano Fit-specific benefits.
Our position is simple: credible science means showing the positive, negative, and uncertain results together. Nano Fit can be accurately described by what is in the water and what can be measured. Claims about what it does inside the human body require direct product-specific evidence.
Continue exploring the science: Dissolved Oxygen vs. Oxygen Nanobubbles and How Nanobubbles Stay Suspended in Water.
References
- Sunardi D, et al. Health effects of alkaline, oxygenated, and demineralized water compared to mineral water among healthy population: a systematic review. Reviews on Environmental Health. 2024;39(2):339–349.
- Daussin FN, et al. Effect of Waters Enriched in O₂ by Injection or Electrolysis on Performance and the Cardiopulmonary and Acid–Base Response to High Intensity Exercise. Nutrients. 2021;13(12):4320.
- Fleming N, Vaughan J, Feeback M. Ingestion of oxygenated water enhances lactate clearance kinetics in trained runners. Journal of the International Society of Sports Nutrition. 2017;14:9.
- Izawa H, et al. Effects of Drinking Oxygenated Water on Blood Oxygen Saturation During Exercise Under Normobaric Hypoxic Conditions. Juntendo Medical Journal. 2022;68(3):228–234.
- Wing-Gaia SL, Subudhi AW, Askew EW. Effects of purified oxygenated water on exercise performance during acute hypoxic exposure. International Journal of Sport Nutrition and Exercise Metabolism. 2005;15(6):680–688.
- Leibetseder V, et al. Does oxygenated water support aerobic performance and lactate kinetics? International Journal of Sports Medicine. 2006;27(3):232–235.
- McNaughton LR, et al. The effect of superoxygenated water on blood gases, lactate, and aerobic cycling performance. International Journal of Sports Physiology and Performance. 2007;2(4):377–385.
- Gruber R, Axmann S, Schoenberg MH. The influence of oxygenated water on the immune status, liver enzymes, and the generation of oxygen radicals. Clinical Nutrition. 2005;24(3):407–414.
- Soyluoglu M, Kim D, Zaker Y, Karanfil T. Stability of Oxygen Nanobubbles under Freshwater Conditions. Water Research. 2021;206:117749.
Science note: This article is educational and is not medical advice. The cited studies evaluated different formulations and protocols. Nano Fit Water was not used in these studies, and their findings should not be interpreted as proof of a Nano Fit-specific outcome.